E-cadherin (Mouse)

E-cadherin mouse antibody is a transmembrane glycoprotein that mediates epithelial cell-cell adhesion. The loss of E-cadherin can result in the disruption of cell clusters. It has been postulated in literature that E-cadherin may function as a tumor suppressor protein. Several studies have associated the loss of E-cadherin with metastasis and poor prognosis in invasive breast cancer. Additional studies have suggested that E-cadherin can help differentiate between ductal and lobular neoplasms of the breast. E-cadherin immunostaining has also been shown to be an independent predictor of disease progression in bladder cancer.

Specifications

Regulatory Notice: Biocare’s IVD-labeled products comply with US-FDA and European IVDD regulation. Other regions may have additional requirements for such labeling, please contact your local distributor.

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2. Byrne RR, et al. J Urol. 2001 May; 165(5):1473-9.
3. Acs G, et al. Am J Clin Pathol. 2001 Jan; 115(1):85-98.