Description
Epidermal Growth Factor Receptor antibody [H11] reacts with a 170kDa (wild type) and 145kDa (vIII variant) protein, identified as the first member of type I family of growth factor receptors (initially identified as EGR-Receptor). The EGFR antibody H11 clone shows no cross reactivity with c-erbB-2, cerbB-3 or c-erbB-4. Various studies have observed and reported over-expression of EGFR in tumors of breast (25%), brain, bladder, lung, gastric, esophagus, cervix, ovary and endometrium.
SPECIFICATIONS
Specifications
| WEIGHT | N/A |
|---|---|
| DIMENSIONS | N/A |
| INTENDED USE | IVD |
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | H11 |
| ISOTYPE | IgG1 |
| ANTIGEN | EGFR |
| LOCALIZATION | Cell membrane and some cytoplasmic |
| POSITIVE CONTROL | Squamous cell carcinoma or skin |
DATASHEETS & SDS
REFERENCES
1. Koo JS, et al. Neoplasma. 2011; 58(1):27-34.
2. Brustmann H, et al. Int J Gynecol Pathol. 2011 Jan; 30(1):76-83.
3. Vranic S, et al. Hum Pathol. 2010 Nov; 41(11):1617-23.
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