Description
The CD68 antibody antigen is a 110 kDa highly glycosylated transmembrane protein which is mainly located in lysosomes. CD68 is commonly regarded as a marker for monocytes and macrophages in many human tissues as well as fibroblasts, endothelial cells and tumor cells. Studies have shown that the CD68 antibody stains blast cells in a large percentage of acute myelogenous leukemia but none in acute lymphoblastic leukemia. Another study showed that [KP1] stained normal/reactive and neoplastic mast cells in lymph node and mastocytosis. The intensity of CD68 staining in individual cell types was found to depend on the fixation technique.
SPECIFICATIONS
Specifications
| INTENDED USE | IVD |
|---|---|
| SPECIES REACTIVITY | Human |
| SOURCE | Mouse Monoclonal |
| CLONE | KP1 |
| ISOTYPE | IgG1/kappa |
| ANTIGEN | CD68 |
| LOCALIZATION | Cytoplasmic |
| POSITIVE CONTROL | Tonsil |
DATASHEETS & SDS
INTERNATIONAL
REFERENCES
1. Horny HP, et al. Hum Pathol. 1993 Apr; 24(4):355-8.
2. Carbone A, et al. Hum Pathol. 1993 Aug; 24(8):886-96.
3. Gottfried E, et al. Scand J Immunol. 2008 May; 67(5):453-63.
4. Kunz-Schughart LA, et al. Verh Dtsch Ges Pathol. 2003; 87:215-23.
5. Horny HP, et al. Hum Pathol. 1994 Aug; 25(8):810-4.
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